Isono was born in 1945 in Aichi Prefecture Japan. He graduated from Aichi University of Education 1968. From 1970, He worked for a corporate design studio and he started his career as a free-lance illustrator. Isono’s work, with its main theme in nature, whether jungle, forest, or tropical, is filled with a serene atmosphere, with the strength and appeal of Nature’s wonder.
In 1991, he provided the main visual for Final Fantasy Adventure (Seiken Densetsu), and would continue providing illustrations for the series. The main artwork from Secret of Mana, Seiken Densetsu 3 and Dawn of Mana, as well as work in Heroes of Mana, were all penned by him.
He sadly passed away on the 28th of May due to heart failure.